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After 21 days, mice were randomized into four different experimental treatment groups: vehicle, cisplatin (4 mg kg 1 once per week for 1 week), RSL3 (50 mg kg 1 , two times per week for 2 weeks) and cisplatin in combination with RSL3

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Tian K, Xu W, Chen M, Deng F

It can be weakened by things like stress, illness, a poor diet, insufficient sleep or lack of activity